Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles. Zhu R et al. Pharm Res. 2012; 29(11):3090-101.
Mechanism of Action
Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents. Sun Y, et al. J Pharmacol Exp Ther. 2011; 338:775-83.